In accordance with the Procedures 1-5 and the USG Policy for Institutional Oversight of Life Sciences Dual Use Research of Concern, Investigators are required to:

1. Notify Regulatory Services as soon as possible, but prior to submitting a funding application, when considering or planning work with nonattenuated forms of one or more of the agents or toxins listed in Section 2. The PI must notify Regulatory Services prior to submitting a funding application, accepting a subaward, or purchasing/receiving DURC agents or toxins (funding applications, subawards, or projects involving DURC that are planned without notification/review by Regulatory Services may be denied, with resultant funding not accepted by the University);
2. Notify the Institutional Review Entity (IRE) as soon as: 
   1. The PI’s research involves nonattenuated forms of one or more of the agents or toxins listed in Section 2;
   2. The PI’s research with nonattenuated forms of one or more of the agents or toxins listed in Section 2also produces, aims to produce, or can be reasonably anticipated to produce one or more of the seven effects listed in Section 3; or
   3. The PI’s research that is within the scope of Section 2 may meet the definition of DURC. The notification must include the PI’s assessment of whether any research involving these agents or toxins produces, aims to produce, or is reasonably anticipated to produce one or more of the effects listed in Section 3.
3. Work with the IRE to assess the dual use risks and benefits of the DURC and to develop risk mitigation measures.
4. Conduct DURC in accordance with the provisions in the risk mitigation plan.
5. Be knowledgeable about and comply with all institutional and USG policies and requirements for oversight of DURC.
6. Ensure that laboratory personnel (i.e., those under the supervision of laboratory leadership, including graduate students, postdoctoral fellows, research technicians, laboratory staff, and visiting scientists) conducting life sciences research with one or more of the agents listed in Section 2 have received education and training on DURC.
7. Communicate DURC in a responsible manner. Communication of research and research findings is an essential activity for all researchers, and occurs throughout the research process, not only at the point of publication. Researchers planning to communicate DURC should do so in compliance with the approved risk mitigation plan.